Matt Huentelman

Matt Huentelman Ph.D.

Professor
Neurogenomics Division

Scientific Director
Center for Rare Childhood Disorders

Head
Neurobehavioral Research Unit

Matt Huentelman Ph.D.

Dr. Huentelman's research interests center around the investigation of the “-omics” (genomics, transcriptomics, and proteomics) of neurological traits and disease. His laboratory’s overarching goal is to leverage findings in these disciplines to better understand, diagnose, and treat human diseases of the nervous system.

Dr. Huentelman joined TGen in July of 2004 after completing his doctoral work at the University of Florida’s Department of Physiology and Functional Genomics at the McKnight Brain Institute where he investigated the application of gene therapy in the study and prevention of hypertension. His undergraduate degree is in Biochemistry from Ohio University’s Department of Chemistry and Biochemistry at Clippinger Laboratories. Dr. Huentelman’s career includes visiting researcher stints in Moscow, Russia at the MV Lomonosov Moscow State University “Biology Faculty” and in the United Kingdom within the University of Bristol’s Department of Physiology. 

Alzheimer’s Disease | The Huentelman lab examines Alzheimer’s disease with the use of next generation DNA and RNA sequencing. They are interested in helping to identify an individual’s personal risk for developing the disease as early as possible in life. This ability will become increasingly important as newer prevention style therapeutics are tested and approved for use. They also undertake the genomic study of phenotypic outliers – like individuals who have extremely high risk for AD but who avoid the disease for their entire life – to better understand how Alzheimer’s progresses and may be prevented.

Aging | Just like other physiological developmental stages our individual response to the process of aging differs dramatically from person to person. Importantly the natural process of aging takes place over many decades and therefore our lifestyle choices and demographic factors may play a major role in how each one of us ages. The Huentelman lab is using genomics and transcriptomics to better understand why some individuals exhibit better cognitive aging when compared to others. The hope is that through the better understanding of these differences we may someday be able to develop therapeutics that could enable a larger portion of the population to exhibit better cognitive aging. 

Cognition | Our individual differences in brain performance remain of great interest to the field of Neuroscience. Dr. Huentelman’s group leverages their innovative web-based approach to study the demographic and genetic drivers of these individual differences in brain performance via their study site at www.mindcrowd.org. The overarching goal of this research is to utilize this new information to improve brain performance in all humans with the hope of enabling greater number of individuals to avoid diseases of cognition or to decrease their severity. 

Rare Disease | The genetic dissection of rare human disease is uniquely powered by our ability to sequence the entire human genome and interpret the results with increasing clarity. The Huentelman laboratory utilizes this approach to tackle rare diseases in children - via TGen’s Center for Rare Childhood Disorders - as well as in adults. The greatest successes in this area come from the study of the entire nuclear family, therefore, Dr. Huentelman’s group typically focuses on the study of diseases that strike at a time in life when the affected patient and parent’s DNA can be studied together.


SELECT PUBLICATONS

Rare Variants in Cardiomyopathy Genes Associated With Stress-Induced Cardiomyopathy. Kalani MY, Siniard AL, Corneveaux JJ, Bruhns R, Richholt R, Forseth J, Zabramski JM, Nakaji P, Spetzler RF, Huentelman MJ. Neurosurgery. 2016 Jun;78(6):835-43.

A De Novo Mutation in TEAD1 Causes Non-X-Linked Aicardi Syndrome. Schrauwen I, Szelinger S, Siniard AL, Corneveaux JJ, Kurdoglu A, Richholt R, De Both M, Malenica I, Swaminathan S, Rangasamy S, Kulkarni N, Bernes S, Buchhalter J, Ramsey K, Craig DW, Narayanan V, Huentelman MJ. Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3896-904.

A Frame-Shift Mutation in CAV1 Is Associated with a Severe Neonatal Progeroid and Lipodystrophy Syndrome. Schrauwen I, Szelinger S, Siniard AL, Kurdoglu A, Corneveaux JJ, Malenica I, Richholt R, Van Camp G, De Both M, Swaminathan S, Turk M, Ramsey K, Craig DW, Narayanan V, Huentelman MJ. PLoS One. 2015 Jul 15;10(7):e0131797.

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease. Giraldo M, Lopera F, Siniard AL, Corneveaux JJ, Schrauwen I, Carvajal J, Muñoz C, Ramirez-Restrepo M, Gaiteri C, Myers AJ, Caselli RJ, Kosik KS, Reiman EM, Huentelman MJ. Neurobiol Aging. 2013 Aug;34(8):2077.e11-8.

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, Nalls MA, Chen K, Lee W, Chewning K, Villa SE, Meechoovet HB, Gerber JD, Frost D, Benson HL, O'Reilly S, Chibnik LB, Shulman JM, Singleton AB, Craig DW, Van Keuren-Jensen KR, Dunckley T, Bennett DA, De Jager PL, Heward C, Hardy J, Reiman EM, Huentelman MJ. Hum Mol Genet. 2010 Aug 15;19(16):3295-301.

Hippocampal gene expression changes during age-related cognitive decline. Pawlowski TL, Bellush LL, Wright AW, Walker JP, Colvin RA, Huentelman MJ. Brain Res. 2009 Feb 23;1256:101-10.

Peripheral delivery of a ROCK inhibitor improves learning and working memory. Huentelman MJ, Stephan DA, Talboom J, Corneveaux JJ, Reiman DM, Gerber JD, Barnes CA, Alexander GE, Reiman EM, Bimonte-Nelson HA. Behav Neurosci. 2009 Feb;123(1):218-23.

Whole-genome analysis of sporadic amyotrophic lateral sclerosis. Dunckley T, Huentelman MJ, Craig DW, Pearson JV, Szelinger S, Joshipura K, Halperin RF, Stamper C, Jensen KR, Letizia D, Hesterlee SE, Pestronk A, Levine T, Bertorini T, Graves MC, Mozaffar T, Jackson CE, Bosch P, McVey A, Dick A, Barohn  R, Lomen-Hoerth C, Rosenfeld J, O'connor DT, Zhang K, Crook R, Ryberg H, Hutton M, Katz J, Simpson EP, Mitsumoto H, Bowser R, Miller RG, Appel SH, Stephan DA. N Engl J Med. 2007 Aug 23;357(8):775-88.

Common Kibra alleles are associated with human memory performance. Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A, Coluccia D, Hänggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ. Science. 2006 Oct 20;314(5798):475-8.

Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2. Strauss KA, Puffenberger EG, Huentelman MJ, Gottlieb S, Dobrin SE, Parod JM, Stephan DA, Morton DH. N Engl J Med. 2006 Mar 30;354(13):1370-7.

Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor. Huentelman MJ, Zubcevic J, Hernández Prada JA, Xiao X, Dimitrov DS, Raizada MK, Ostrov DA. Hypertension. 2004 Dec;44(6):903-6. Epub 2004 Oct 18.

 


Christiane Bleul
Research Associate II
602-343-8631
cbleul@tgen.org

Matt De Both
Bioinformatician
602-343-8698
mdeboth@tgen.org

Adrienne Henderson
Research Associate
602-343-8507
ahenderson@tgen.org

Wayne Jepsen

Research Associate
602-343-8821
wjepsen@tgen.org

Valerie Jones

Executive Assistant
602-343-8767
vjones@tgen.org

Candace Lewis, Ph.D.
Post-Doctoral Fellow
602-343-8467
clewis@tgen.org
Marcus Naymik
Associate Bioinformatician
602-343-8416
mnaymik@tgen.org

Joshua Talboom, Ph.D.

Post-Doctoral Fellow
602-343-8433
jtalboom@tgen.org

Nicholas Walker
Intern
nwalker@tgen.org

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