One Health Collaborative
TGen One Health Collaborative seeks to understand the larger health problems of our time through a comprehensive approach to studying impacts in humans, animals and the environment. We can then apply next generation technology and knowledge to address these problems in a holistic manner that understands the microbial universe is shared among all living systems.

We will work directly with other health researchers, physicians, health care workers and public health officials; wildlife managers, ranchers and agriculture; and environmental health and quality officials to apply these approaches for basic and translational research to maximize health impacts.

Strategic Focus Areas
  • Our approach: Human, Animal and Environment
  • Population health and genomic epidemiology
  • Antibiotic resistance and healthcare acquired infections
  • Diagnostic and prognostic tool development and translation
  • Microbial evolution, pathogen dispersal and emerging infections

Healthcare Acquired Infections

Approximately 1.7 million cases of Healthcare Acquired Infections (HAI) occur each year in US hospitals, resulting in an estimated 99,000 deaths and costing over $20 Billion. Each and every case is preventable. HAIs can result from contaminated medical equipment, lapses in proper infection control procedures, or failure to follow standard procedures (i.e., overuse of catheters). Additionally, HAI-causing microbes can be introduced by healthcare staff, other patients, hospital visitors, the healthcare environment, and even the patient themselves.

A critically dangerous HAI pathogen is the the bacteria Clostridium difficile (aka "C. diff"), which kills nearly 30,000 Americans per year. C. diff is a direct result of the use of antibiotics and typically shows up when the normal bacteria in the patient's gut is killed off, leading to C. diff causing painful and sometimes deadly GI infections. What's not as well known is that humans aren't the only carriers of C. diff — our pets, namely dogs, are also infected. TGen researchers and partners are exploring this One Health connection between humans and pets to increase our understanding of the sources of these pathogens and provide better tools to physicians and veterinarians to track and control C. diff and other HAI infections.

Contact Information

Please contact the TGen Foundation at:

Paul Keim Ph.D.

Distinguished Professor and Co-Director
Pathogen and Microbiome Division

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David Engelthaler Ph.D.

Associate Professor and Co-Director
Pathogen and Microbiome Division

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Jolene Bowers Ph.D.

Research Assistant Professor
Pathogen and Microbiome Division

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One Health Collaborative

To address the greatest public health threats, we track outbreaks, create better diagnostics and smarter treatments.