The Collaborative Center for Translational Mass Spectrometry (CCTMS) and the laboratory of Dr. Patrick Pirrotte are a full-service, next generation proteomics and small molecule based facility providing end-to-end solutions tailored for translational and clinical research. With over 10 years experience collaborating with leading academic, biotech, pharma and industry partners, the CCTMS delivers innovative and customized services in mass spectrometry based biotechnologies.
Disease and Systems Biology Applications
The CCTMS employs highly sensitive mass spectrometry approaches to perform ultra-deep proteomics profiling (i.e., >90% of the expressed proteome) in tissues and tumors. Assays are tailored towards clinical proteomics needs, such as FFPE proteomics or biomarker discovery in biofluids (e.g., plasma, serum, urine, saliva). Approaches for metaproteomic and metabolic profiling of microbial pathogens and microbiomes in longitudinal clinical samples have been established.
In addition, the Center has developed unique approaches that enable comprehensive and functional characterization of protein phosphorylation and kinome discovery to map key signaling pathways in support of the development of novel targeted therapies. Its bioinformatics pipeline provides data integration across proteomics, metabolomics, genomics and transcriptomics to provide a united and actionable overview of tumor biology in precision medicine clinical trials.
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Patrick Pirrotte, Ph.D. Assistant Professor, Cancer and Cell Biology Division Director, Collaborative Center for Translational Mass Spectrometry