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Scientists Warm Up to HIPEC Therapy for Ovarian Cancer

Dr. Thanh H. Dellinger discusses using Heated Intraperitoneal Chemotherapy (HIPEC) to circulate heated chemotherapy inside the abdominal cavity at the time of surgery to allow direct treatment of cancers that have spread throughout the abdomen.

Dr. Thanh H. Dellinger, City of Hope Assistant Professor in the Division of Gynecologic Oncology, Department of Surgery, gave a Scientific Seminar to a standing-room crowd on Wednesday, January 24 at TGen.

She discussed a new approach to advanced stage ovarian and endometrial cancers, called Heated Intraoperative Peritoneal Chemotherapy (HIPEC). Instead of infusing chemotherapy intravenously after surgery, her team uses HIPEC to circulate heated chemotherapy inside the abdominal cavity at the time of surgery. The team will then rock the patient gently for up to an hour to ensure the chemo moves through the patient's belly before closing up again.

This technique allows direct treatment of cancers that have spread throughout the abdomen. These are large and complex surgeries that can last more than six hours, and HIPEC can reduce the lag-time between surgery and the first chemotherapy regimen. HIPEC also can attack microscopic remnants of the disease and tumor 'floaters.' TGen scientists discussed how our genomics platforms and discoveries in ovarian cancer could help differentiate patients which may respond best, as well as help determine biomarkers.

This exchange of ideas between City of Hope clinicians and TGen scientists will only serve to broaden our approaches to cancer and other complex diseases while delivering personalized hope to patients everywhere.

Learn more about this innovative HIPEC procedure: https://www.cityofhope.org/heated-intraperitoneal-chemotherapy

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