Khyati Pathak

Khyati Pathak Ph.D.

Research Assistant Professor
Cancer and Cell Biology Division

Khyati Pathak Ph.D.

Dr. Pathak received her Ph.D. in Microbiology from Sardar Patel University, India. Her sub-sequent post-doctoral training took place at University of Minnesota with Dr. Turesky and, most recently, at TGen with Dr. Pirrotte.

In 2021, Dr. Pathak was named Head of the Metabolomics unit, which operates under the direct leadership of Dr. Pirrotte. In this role, she is responsible for the development of novel analytical assays as well as the successful execution collaborative research projects in metabolomics or lipidomics. To date, Dr. Pathak has developed and validated more than 15 mass spectrometry-based assays to quantify small molecules and metabolites which are routinely performed in the metabolomics unit. Over the years, she has conducted several large cohort studies on a wide variety of clinical and non-clinical, samples.

As a Research Assistant Professor in the Cancer and Cell Biology Division, Dr. Pathak’s research is focused on utilizing untargeted and quantitative metabolomics as well as lipidomics approaches to understand metabolic deregulation in pathological conditions including cancer, neurological disorders, and infectious diseases. She leverages this knowledge in early detection to predict disease progression and to identify therapeutic targets. At present, Dr. Pathak’s research is primarily focused on understanding the mechanism of reversal of deregulated energy metabolism upon targeting polyamine metabolism in medulloblastoma. Her research also explores exposome where she is interested in biomonitoring environmental toxicants and carcinogens to understand their effect on human health.

Deregulated metabolism in cancer

Wang H, He X, Zhang L, Dong H, Huang F, Xian J, Li M, Chen W, Lu X, Pathak KV, Huang W, Li Z, Zhang L, Nguyen LXT, Yang L, Feng L, Gordon DJ, Zhang J, Pirrotte P, Chen CW, Salhotra A, Kuo YH, Horne D, Marcucci G, Sykes DB, Tiziani S, Jin H, Wang X, Li L. Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade. Blood. 2022.

Liefwalker DF, Ryan M, Wang Z, Pathak KV, Plaisier S, Shah V, Babra B, Dewson GS, Lai IK, Mosley AR, Fueger PT, Casey SC, Jiang L, Pirrotte P, Swaminathan S, Sears RC. Metabolic convergence on lipogenesis in RAS, BCR-ABL, and MYC-driven lymphoid malignancies. Cancer Metab. 2021 

Biomarker research

Saber M, Pathak KV, McGilvrey M, Garcia-Mansfield K, Harrison JL, Rowe RK, Lifshitz J, Pirrotte P. Proteomic analysis identifies plasma correlates of remote ischemic conditioning in the context of experimental traumatic brain injury. Sci Rep. 2020.

Exposomics research

Winstone JK, Pathak KV, Winslow W, Piras IS, White J, Sharma R, Huentelman MJ, Pirrotte P, Velazquez R. Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders. J Neuroinflammation. 2022

Early detection in infectious diseases

Pathak KV, McGilvrey MI, Hu CK, Garcia-Mansfield K, Lewandoski K, Eftekhari Z, Yuan YC, Zenhausern F, Menashi E, Pirrotte P. Molecular Profiling of Innate Immune Response Mechanisms in Ventilator-associated Pneumonia. Mol Cell Proteomics. 2020

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