Floris Barthel
Floris Barthel

Floris Barthel

Assistant Professor
Cancer and Cell Biology Division

Floris Barthel

Assistant Professor at the Cancer and Cell Biology Division at the Translational Genomics Institute (TGen) and the Department of Computational and Quantitative Medicine (DCQM) at the Beckman Research Institute (BRI) at City of Hope (COH). Floris did his postdoc in the laboratory of Roel Verhaak at the MD Anderson Cancer Center and later at the Jackson Laboratory where he studied the molecular makeup of glial brain tumors. During these years, he published first-author papers in top-tier journals including Nature and Cell, and perhaps more importantly, his work played a small part in recent updates to the World Health Organization guidelines for the classification of brain tumors.

His ongoing research aims to dissect the role of telomere dysfunction in gliomagenesis using high-throughput sequencing and computational analysis. Floris will determine the mutational signatures of telomere dysfunction and provide an accurate picture of the role of this process in shaping cancer genomes. Supported by a K99/R00 transitional award from the National Cancer Institute he is funded to interrogate the strategies of telomere maintenance in cancer cells. Recent awards include being named a Forbeck Scholar by the William Guy Forbeck Research Foundation and being awarded the Research Rising Star Award by the Brain Tumor Charity.

Radiotherapy is associated with a deletion signature that contributes to poor outcomes in patients with cancer

Kocakavuk E, Anderson KJ, Varn FS, Johnson KC, Amin SB, Sulman EP, Lolkema MP, Barthel FP, Verhaak RGW. Nat Genet. 2021 Jul;53(7):1088-1096. doi: 10.1038/s41588-021-00874-3. Epub 2021 May 27. PubMed PMID: 34045764; PubMed Central PMCID: PMC8483261.

Spatial concordance of DNA methylation classification in diffuse glioma

Verburg N, Barthel FP, Anderson KJ, Johnson KC, Koopman T, Yaqub MM, Hoekstra OS, Lammertsma AA, Barkhof F, Pouwels PJW, Reijneveld JC, Rozemuller AJM, Beliën JAM, Boellaard R, Taylor MD, Das S, Costello JF, Vandertop WP, Wesseling P, de Witt Hamer PC, Verhaak RGW. Neuro Oncol. 2021 May 28;. doi: 10.1093/neuonc/noab134. [Epub ahead of print] PubMed PMID: 34049406.

Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. 

Wen PY, Weller M, Lee EQ, Alexander BM, Barnholtz-Sloan JS, Barthel FP, Batchelor TT, Bindra RS, Chang SM, Chiocca EA, Cloughesy TF, DeGroot JF, Galanis E, Gilbert MR, Hegi ME, Horbinski C, Huang RY, Lassman AB, Le Rhun E, Lim M, Mehta MP, Mellinghoff IK, Minniti G, Nathanson D, Platten M, Preusser M, Roth P, Sanson M, Schiff D, Short SC, Taphoorn MJB, Tonn JC, Tsang J, Verhaak RGW, von Deimling A, Wick W, Zadeh G, Reardon DA, Aldape KD, van den Bent MJ. Neuro Oncol. 2020 Aug 17;22(8):1073-1113. doi: 10.1093/neuonc/noaa106. Review. PubMed PMID: 32328653; PubMed Central PMCID: PMC7594557.

DNA methylation classification in diffuse glioma shows little spatial heterogeneity after adjusting for tumor purity

Verburg N, Barthel FP, Anderson KJ, Johnson KC, Koopman T, Yaqub MM, Hoekstra OS, Lammertsma AA, Barkhof F, Pouwels PJ, Reijneveld JC, Rozemuller AJ, Boellaard R, Taylor MD, Das S, Costello JF, Vandertop WP, Wesseling P, Verhaak RG.  [preprint]. 2020 March. Available from: https://www.biorxiv.org/content/10.1101/2020.03.28.012732v1. doi: 10.1101/2020.03.28.012732.

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