Eric Reiman

Eric Reiman M.D.

Professor and Clinical Director
Neurogenomics Division

Eric Reiman M.D.

Dr. Reiman is Executive Director of the Banner Alzheimer's Institute, Chief Executive Officer of Banner Research, Clinical Director of Neurogenomics at the Translational Genomics Research Institute, Professor of Psychiatry at the University of Arizona, University Professor of Neuroscience at Arizona State University, and Director of the Arizona Alzheimer's Consortium. He and his Banner Alzheimer's Institute colleagues Drs. Pierre Tariot and Jessica Langbaum lead the Alzheimer's Prevention Initiative (API), which has helped to introduce a new era in Alzheimer's prevention research.

Dr. Reiman received his undergraduate and medical degrees at Duke University and his Psychiatry Residency training at Duke and Washington University in St. Louis. Launching his research career as a resident and faculty member under Dr. Marcus Raichle, he and his colleagues introduced brain imaging paradigms and image analysis techniques that have had a profound impact on the study of the human mind and brain.

Dr. Reiman is internationally recognized for his pioneering contributions in brain imaging, genomics, and the cognitive and behavioral neurosciences, the unusually early detection and tracking of Alzheimer's disease, and the accelerated evaluation of Alzheimer's prevention therapies. He and his colleagues hope to provide the evidence needed to help establish a new national standard of dementia care by 2020, they hope to find and support the approval of effective Alzheimer's prevention therapies by 2025, and they have continued to find new ways for researchers from different disciplines and organizations to work together in support of their ambitious goals.

Dr. Reiman an author of more than 300 publications, a principal investigator of several large NIH grants, and a recipient of the Potamkin Prize.

  • Fonseca R, Bergsagel PL, Drach J, Shaughnessy J, Gutierrez N, Stewart K, Morgan G, Van Ness B, Chesi M, Minvielle S, Neri A, Barlogie B, Kuehl WM, Liebisch P, Davies F, Chen Kiang S, Durie BGM, Carrasco R, Sezer O, Reiman T, Pilarski L, Avet-Loiseau H. , International Myeloma Working Group molecular classification of multiple myeloma: spotlight review. Leukemia Oct;Epub 2009
  • Reiman, E.M., Chen, K., Alexander, G.E., Caselli, R.J., Bandy, D., Osborne, D., Saunders, A.M., Hardy, J., Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia. , submitted, 2003.
  • Valla, J., Chen, K., Berndt, J.D., Gonzalez-Lima, F., Cherry, S.R., Games, D., Reiman, E.M.. , Effects of image resolution on autoradiographic measurements of posterior cingulated activity in PDAPP mice: Implications for functional brain imaging studies in transgenic mouse models of Alzheimer's disease. NeuroImage 16:1, 6 2002
  • Alexander, G.E., Chen, K., Pietrini, P., Rapoport, S.I., Reiman, E.M.. , Longitudinal evaluation of cerebral metabolic decline in dementia: Implications for using resting PET to measure outcome if long-term treatment studies of Alzheimer's disease. Am J Psychiatry 159:738, 745. 2002
  • Reiman, E.M., Caselli, R.J., Alexander, G.E., Chen, K., Tracking the decline in cerebral glucose metabolism in persons and laboratory animals at genetic risk for Alzheimer's disease Clin Neurosci Res, 1:194, 206. 2001
  • Reiman, E.M., Caselli, R.J., Chen, K., Alexander, G.E., Bandy, D., Frost, J.. , Declining brain activity in cognitively normal apolipoprotein E e4 heterozygotes: a foundation for testing Alzheimers disease prevention therapies using positron emission tomography to efficiently test treatments to prevent Alzheimers disease. Proc Nat Acad Sci USA 98: 3334,3339. 2001
  • Craig DW, Itty A, Panganiban C, Szelinger S, Kruer MC, Sekar A, Reiman D, Narayanan V, Stephan DA, Kerrigan JF. , Identification of somatic chromosomal abnormalities in hypothalamic hamartoma tissue at the GLI3 locus American Journal of Human Genetics 82(2):366-74 2008
  • Webster JA, Myers AJ, Pearson JV, Craig DW, Hu-Lince D, Coon KD, Zismann VL, Beach T, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Huentelman MJ, Joshipura K, Walker D, Heward CB, Ravid R, Rogers J, Papassotiropoulos A, Hardy J, Reiman EM, Stephan DA., Sorl1 as an Alzheimer's disease predisposition gene? Neurodegener Dis 5(2):60-4. 2008
  • Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert (Robeson) RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA., GAB2 alleles modify Alzheimer's risk in APOE varepsilon4 carriers. Neuron 54(5): 713-720. 2007
  • Myers AJ, Gibbs JR, Webster JA, Rohrer K, Zhao A, Marlowe L, Kaleem M, Leung D, Bryden L, Nath P, Zismann VL, Joshipura K, Huentelman MJ, Hu-Lince D, Coon KD, Craig DW, Pearson JV, Holmans P, Heward CB, Reiman EM, Stephan D, Hardy J. , A survey of genetic human cortical gene expression. Nat Genet 39(12):1494-9. 2007
  • Pearson JV, Huentelman MJ, Halperin RF, Tembe WD, Melquist S, Homer N, Brun M, Szelinger S, Coon KD, Zismann VL, Webster JA, Beach T, Sando SB, Aasly JO, Heun R, Jessen F, Kolsch H, Tsolaki M, Daniilidou M, Reiman EM, Papassotiropoulos A, Hutton ML, Stephan DA, Craig DW., Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies Am J Hum Genet, Jan;80(1):126-39 2007
  • Kerrigan JF, Craig DW, Kruer MC, Corneveaux JJ, Panganiban CB, Itty A, Reiman D, Ng YT, Stephan DA., Chromosomal Abnormality at 6p25.1-25.3 Identifies A Susceptibility Locus For Hypothalamic Hamartoma Associated With Epilepsy. Epilepsy Res 75(1):70-3 2007
  • Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A,Coluccia D, Hanggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ. , Common Kibra alleles are associated with human memory performance. Science Oct 20;314(5798):475-8 2006
  • Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ., Evidence for an association between KIBRA and late-onset Alzheimer's disease Neurobiology of Aging Jun;31(6):901-9. 2010
  • Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, Nalls MA, Chen K, Lee W, Chewning K, Villa SE, Meechoovet HB, Gerber JD, Frost D, Benson HL, O'Reilly S, Chibnik LB, Shulman JM, Singleton AB, Craig DW, Van Keuren-Jensen KR, Dunckley T, Bennett DA, De Jager PL, Heward C, Hardy J, Reiman EM, Huentelman MJ, Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals Hum Mol Genet Aug 15;19(16):3295-301 2010
  • Huentelman MJ, Stephan DA, Talboom J, Corneveaux JJ, Reiman DM, Gerber JD, Barnes CA, Alexander GE, Reiman EM, Bimonte-Nelson HA. , Peripheral delivery of a ROCK inhibitor improves learning and working memory. Behav Neurosci. Feb;123(1):218-23 2009
  • Huentelman MJ*, Papassotiropoulos A*, Craig DW, Hoerndli FJ, Pearson JV, Huynh K-D, Corneveaux J, Hänggi J, Mondadori CRA, Buchmann A, Reiman EM, Henke K, de Quervain D J-F, Stephan DA. *equal contribution from these author, Calmodulin-binding Transcription Activator 1 (CAMTA1) Alleles Predispose Human Episodic Memory Performance. Hum Mol Genet Jun 15;16(12):1469-77 2007
  • Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA., Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology. Neurobiol Aging, 31:549-66 2010
  • Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA., Altered neuronal gene expression in brain regions differentially affected by Alzheimer's Disease: A reference data set. Physiological Genomics 33(2): 240-56 2008
  • Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, Niedzielko TL, Schneider LE, Mastroeni D, Caselli R, Kukull W, Morris JC, Hulette CM, Schmechel D, Roger J, Stephan DA. , Alzheimer's Disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons Proc Natl Acad Sci USA, 105(11): 4441-6 2008
  • Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Walker DG, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette C, Schmechel D, Alexandar GE, Reiman EM, Rogers J, Stephan DA., Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain Physiological Genomics 28(3):311-322 2007
  • Dunckley T, Beach TG, Ramsey KE, Grover A, Mastroeni D, Walker DG, Lafleur BJ, Coon KD, Brown KM, Caselli R, Kukull W, Higdon R, McKeel D, Morris JC, Hulette C, Schmechel D, Reiman EM, Rogers J, Stephan DA., Gene expression correlates of neurofibrillary tangles in Alzheimer's disease. Neurobiology of Aging 27(10):1359-71 2006
  • Papassotiropoulos A, Fountoulakis M, Dunckley T, Stephan DA, Reiman EM., Genetics, Transcriptomics and Proteomics of Alzheimer's Disease J. Clin. Psych 67: 652-670 2006
  • Keats JJ, Reiman T, Belch AR, Pilarski LM. , Ten Years and Counting: So what do we know about t(4;14)(p16q;32) Multiple Myeloma. Leukemia and Lymphoma 47(11):2289-3000 2006
  • Keats JJ, Maxwell CA, Taylor BJ, Chesi C, Bergsagel PL, Larratt LM, Mant MJ, Reiman T, Belch AR, Pilarski LM., Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32) positive multiple myeloma patients. Blood 105(10):4060-4069 2005
  • Keats JJ, Reiman T, Maxwell CA, Taylor BJ, Larratt LM, Mant MJ, Belch AR, Pilarski LM., In Multiple Myeloma, t(4;14)(p16;q35) is an adverse prognostic factor irrespective of FGFR3 expression Blood 101(4):1520-1529 2003
  • Liang WS, Chen K, Lee W, Sidhar K, Corneveaux JJ, Allen AN, Myers A, Villa S, Meechoovet B, Pruzin J, Bandy D, Fleisher AS, Langbaum JB, Huentelman MJ, Jensen K, Dunckley T, Caselli RJ, Kaib S, Reiman EM. . , Association between GAB2 haplotype and higher glucose metabolism in Alzheimer's disease-affected brain regions in cognitively normal APOEepsilon4 carriers Neuroimage 54(3), 54(3):1896-902. 2010
  • Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, Niedzielko TL, Schneider LE, Mastroeni D, Caselli R, Kukull W, Morris JC, Hulette CM, Schmechel D, Roger J, Stephan DA., Alzheimer's Disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc Natl Acad Sci USA 105(11): 4441-6. 2008
  • Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA., Neuronal gene expression in non-demented individuals with Alzheimer's Disease neuropathology. Neurobiology of Aging Epub 2008
  • Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Walker DG, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette C, Schmechel D, Alexandar GE, Reiman EM, Rogers J, Stephan DA. , Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. Physiological Genomics 28(3):311-322 2007
  • Webster JA, Gibbs JR, Clarke J, Ray M, Zhang W, Holmans P, Rohrer K, Zhao A, Marlowe L, Kaleem M, McCorquodale DS 3rd, Cuello C, Leung D, Bryden L, Nath P, Zismann VL, Joshipura K, Huentelman MJ, Hu-Lince D, Coon KD, Craig DW, Pearson JV; NACC-Neuropathology Group, Heward CB, Reiman EM, Stephan D, Hardy J, Myers AJ, Genetic control of human brain transcript expression in Alzheimer disease Am J Hum Genet 84(4):445-58 2009
  • Coon KD, Myers AJ, Craig DW, Webster JA, Pearson JV, Lince DH, Zismann VL, Beach TG, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Walker DG, Ravid R, Heward CB, Rogers J, Papassotiropoulos A, Reiman EM, Hardy J, Stephan DA, A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease. J Clin Psychiatry 68(4):613-8. 2007
  • Coon KD, Valla J, Szelinger S, Schneider LE, Niedzielko TL, Brown KM, Pearson JV, Halperin R, Dunckley T, Papassotiropoulos A, Caselli RJ, Reiman EM, Stephan DA., Quantitation of heteroplasmy of mtDNA sequence variants identified in a population of AD patients and controls by array-based resequencing Mitochondrion July 21 2006
Back To Top