Arizona Researchers Receive 2.5-million NIH award to Study Gene
Expression and it's Impact on Treatment of Alzheimer's
Disease
October 29, 2003
A $2.5 million five-year grant from the National Institutes of
Health (NIH) awarded to The Translational Genomics Research
Institute (TGen) and the Arizona Alzheimer's Disease Consortium
(ADC) will enable investigation into the early causes of
Alzheimer's disease (AD), the most common form of memory loss and
brain disorders in older persons. This NIH grant combines the
expertise and resources of the ADC and TGen.
The project's principal investigator is Dr. Dietrich Stephan,
Director of Neurogenomics at TGen. The co-principal investigators
are Drs. Joe Rogers, President and Senior Scientist at the Sun
Health Research Institute, and Eric Reiman, Director of the Arizona
ADC.
"This collaboration has allowed us to become one of only three
centers in the US awarded funds for this project. With the national
competition for grant dollars severe, this award not only
emphasizes the importance of this research, but is the first of
what I hope is a great deal of research funding coming to the state
of Arizona due in part to these types of collaborations," said Dr.
Rogers.
The planned study seeks to provide new information about the genes
that are turned on or off in the brains of patients with AD and how
these genes contribute to each of the microscopic and brain imaging
abnormalities found in these individuals. New information will also
be sought about the genes that are most affected by normal aging.
The findings will contribute to a scientific database for
researchers around the world, supporting further studies of AD and
brain aging, and assisting in the discovery of drugs to treat these
conditions.
"Information about the genes expressed during the course of
Alzheimers disease could improve our understanding of the molecular
mechanisms involved in the development of this catastrophic and
increasingly common disease," said Dr. Stephan.
This collaborative research study is funded by the National
Institute on Aging (NIA) and includes scientists from TGen, the
NIA-sponsored Alzheimer's Disease Centers in Arizona, Washington
University in St. Louis, Duke University, University of Washington,
and the National Alzheimer's Coordinating Center. Researchers
working on this project from the Arizona ADC are located at the Sun
Health Research Institute, Mayo Clinic Scottsdale, and Banner Good
Samaritan Medical Center.
Sun Health's Rogers believes his Institute's research on AD can be
accelerated in part through its collaboration with TGen.
"This research award takes advantage of TGen's state-of-the-art
methods in genetics, genomics, and proteomics, its commitment to
the study of brain disorders," says Dr. Rogers. "Their expertise
dovetails nicely with the progress we've made through our research
efforts."
The Arizona ADC's remarkable brain donation program, located at
the Sun Health Research Institute, and the ADC's internationally
recognized strengths in the brain imaging and basic neuroscientific
study of AD will add greatly to the study. Study findings could
provide new targets against which to aim drugs for the treatment
and prevention of AD, and perhaps even targets against which to aim
anti-aging therapies. Data from the study will be deposited into a
public database administered by the NINDS/NIMH Array Consortium,
which will allow other scientists to conduct further
analyses.
"We are extremely excited about the chance to capitalize on
Arizona's remarkable scientific resources in the study of AD," says
Dr. Reiman, Clinical Director of Neurogenomics at TGen and Director
of the ADC, "and we're excited about the chance to help in the
scientific effort to create a world without Alzheimer's."
"This is the first of what we hope are many genetic, genomic, and
proteomic studies to further understand a disease that afflicts so
many people in our State and around the world," said Stephan.
About TGen
The mission of the Translational Genomics Research Institute
(TGen) is to make and translate genomic discoveries into advances
in human health. "Translational genomics research" is a relatively
new field employing innovative advances arising from the Human
Genome Project to apply to the development of diagnostics,
prognostics and therapies for cancer, neurologic disorders,
diabetes and other complex diseases.
About the Arizona ADC
The Arizona ADC is a statewide research program involving eight of
the states leading biomedical research organizations. It includes
the state-supported Arizona Alzheimer's Research Center and the
NIA-sponsored Arizona Alzheimer's Disease Core Center.
About Sun Health Research Institute
Sun Health Research Institute is a non-profit center dedicated to
studies of aging and age-related diseases. Scientists at the
Institute are internationally recognized at all levels, from the
laboratory to the clinic. The Institute's brain bank, one of the
largest in the world for Alzheimer's research, provides to hundreds
of scientists critical tissue samples on which studies such as the
collaboration with TGen depend.
Contact:
Galen Perry
602.343.8423
[email protected]