Winnie Liang

Winnie Liang Ph.D.

Assistant Professor
Integrated Cancer Genomics and Neurogenomics Divisions

Director
Scientific Operations

Director

Collaborative Sequencing Center

Winnie Liang Ph.D.

Dr. Liang is Director of the Collaborative Sequencing Center (CSC), Assistant Professor in the Integrated Cancer Genomics and Neurogenomics Divisions, and Director of Scientific Operations at TGen. In 2010, Dr. Liang led the creation of the CSC, which acts as TGen’s primary next-generation sequencing resource. The center performs library construction and next-generation sequencing of whole genomes, exomes, ChIP DNA, and RNA on the Illumina platform, and has an emphasis on collaborative projects. Since its inception, the CSC has completed over 600 projects and has generated over 280Tb of raw sequencing data for studies encompassing a wide spectrum of diseases including DIPG (diffuse intrinsic pontine glioma), pancreatic cancer, cholangiocarcinoma, cutaneous and acral melanomas, Sézary syndrome, breast cancer, Alzheimer’s disease, diffuse large B-cell lymphoma, and breast cancer. The CSC has been involved in numerous studies including the longitudinal Multiple Myeloma Research Foundation (MMRF) study, the SU2C Genomics-Enabled Medicine for Melanoma trial, and clinical sequencing studies.

Dr. Liang’s research areas include cell-specific transcriptomics in Alzheimer’s disease, cancer genomics, and evaluating phenotypic variability in tuberous sclerosis, as well as precision medicine studies in DIPG and other cancers. Ms. Liang received her Bachelor of Science in Biological Sciences (Computational Biology Option) from Carnegie Mellon University, and her Ph.D. from Arizona State University in Molecular and Cellular Biology.


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SELECT PUBLICATONS

ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. Mastroeni D, Sekar S, Delvaux E, Nolz J, Liang WS, Coleman PD (2017). PLoS ONE 12(7):e0177814.

Phenotypic variability and mTOR pathway gene aberrations in familial tuberous sclerosis. Liang WS, Sekar S, Nasser S, Adkins J, Cuyugan L, Enriquez D, Rangasamy S, Narayanan V (2017). J Ped Neurol (accepted).

Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma. Liang WS, Hendricks W, Kiefer J, Schmidt J, Sekar S, Carpten J, Craig DW, Adkins J, Cuyugan J, Manojlovic Z, Halperin RF, Helland A, Nasser S, Legendre C, Hurley LH, Sivaprakasam K, Johnson DB, Crandall H, Busam KJ, Zismann V, Deluca V, Lee J, Sekulic A, Ariyan CE, Sosman J, Trent J (2017). Gen Research 27(4):524-532.

A somatic reference standard for cancer genome sequencing. Craig DW, Nasser S, Corbett R, Chan SK, Murray L, Legendre C, Tembe W, Adkins J, Kim N, Wong S, Baker A, Enriquez D, Pond S, Pleasance E, Mungall AJ, Moore RA, McDaniel T, Ma Y, Jones SJM, Marra MA, Carpten JD, Liang WS (2016) Scientific Reports 6:24607.

Alzheimer’s disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes. Sekar S, McDonald J, Cuyugan L, Aldrich J, Kurdoglu A, Adkins J, Serrano G, Beach TG, Craig DW, Valla J, Reiman EM, Liang WSNeurobiology of Aging. 2015, 36(2):583-91.


Lori Cuyugan

Research Associate III
602-343-8776
lcuyugan@tgen.org

Erica Tassone

Staff Scientist
602-343-8523
etassone@tgen.org

Valerie Jones

Executive Assistant
602-343-8767
vjones@tgen.org
Jonathan Adkins
Research Associate  III
602-343-8520
jadkins@tgen.org

Jerry Antone

Research Associate II
602-343-8505
jantone@tgen.org


Philipp Geiger

Research Associate
602-343-8574
pgeiger@tgen.org

Shobana Sekar
Graduate Student, Bioinformatics
602-343-8544
SSekar@tgen.org

Daniel Enriquez

Research Technician
602-343-8539
denriquez@tgen.org

 














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