Lance B. Price

Lance B. Price Ph.D.

Associate Professor
Pathogen and Microbiome Division

Professor
Milken Institute School of Public Health
George Washington University 

Lance B. Price Ph.D.

As the director of the TGen North's Center for Microbiomics and Human Health, Dr. Lance Price is developing cutting-edge methods for characterizing the microbial communities that form the human microbiome, which is all of the bacteria that exist on and in the human body.

Dr. Price's research will eventually lead to a better understanding of the human body's microbial ecosystem and its relationship to our health. His translational goals are to develop rapid tests to diagnose microbial infections and to develop novel therapies to eliminate pathogenic microbes without disrupting the microbes critical to good health.

Dr. Price works with researchers at the Johns Hopkins University, the New York University, the University of Maryland, the University of Toronto, and the Arizona Burn Center at Maricopa Integrated Health Systems, to characterize the bacteria and fungi that colonize body sites ranging from the genitalia to the middle ear and diseases ranging from chronic wounds to chronic sinus inflammation.

Dr. Price is also studying the sources and spread of antibiotic resistant bacterial pathogens. Over the past 70 years, antibiotics have been used to treat millions of people and save countless lives. Unfortunately, over the past few decades we have observed the emergence of bacterial pathogens that are resistant to many - sometimes all - of our clinically approved antibiotics. Dr. Price is using molecular tools to uncover the sources of antibiotic resistant bacteria and identify ways to interrupt the spread of these potentially deadly organisms.

Dr. Price is an Arizona native. He received his B.S. in Microbiology and M.S. in Biology from Northern Arizona University (NAU), where he led Anthrax and Plague research projects in Dr. Paul Keim's molecular genetics laboratory. In 2000, Dr. Price moved to Baltimore and worked for a small biotech company before matriculating to the Johns Hopkins Bloomberg School of Public Health. In 2003, Dr. Price became a Center for a Livable Future Pre-doctoral Fellow, characterizing public health risks associated with antibiotic use in industrial food-animal production. In 2006, Dr. Price completed his Ph.D. in Environmental Health Science, before joining the research faculty at the Johns Hopkins School of Medicine, where he worked with his colleagues to characterize the complex bacterial communities that colonize chronic wounds, before joining TGen.

  • Malhotra A, Coon H, Feitosa MF, Li WD, North KE, Price RA, Bouchard C, Hunt SC, Wolford (DiStefano) JK; The American Diabetes Association GENNID Study Group., Meta-analysis of genome-wide linkage studies for quantitative lipid traits in African Americans. Hum Mol Genet 15;14(24):3955-62. 2005
  • Braggio E, Keats J, Leleu X, Remstein E, Van Wier S, Jimenez-Zepeda V, Valdez R, Schop R, Price-Troska T, Henderson K, Sacco A, Azab F, Greipp P, Gertz M, Hayman S, Rajkumar V, Carpten J, Chesi M, Barrett M, Stewart AK, Dogan A, Bergsagel PL, Ghobrial I, Fonseca R. , Identification of copy-number abnormalities and inactivating mutations in two negative regulators of NF-kB signaling pathways in Waldenström's Macroglobulinemia. Cancer Research Apr 15;69(8):3579-88. 2009
  • Tiedemann RE, Gonzalez-Paz N, Kyle RA, Santana-Davila R, Price-Troska T, Van Wier SA, Chng WJ, Ketterling RP, Gertz MA, Henderson K, Greipp PR, Dispenzieri A, Lacy MQ, Rajkumar SV, Bergsagel PL, Stewart AK, Fonseca R., Genetic aberrations and survival in plasma cell leukemia. Leukemia 22(5):1044-52 2008
  • Keats JJ, Fonseca R, Chesi M, Schop R, Baker A, Chng WJ, Van Wier S, Tiedemann R, Shi CX, Sebag M, Braggio E, Henry T, Zhu YX, Fogle H, Price-Troska T, Ahmann G, Mancini C, Brents LA, Kumar S, Greipp P, Dispenzieri A, Bryant B, Mulligan G, Bruhn L, Barrett M, Valdez R, Trent J, Stewart AK, Carpten J, Bergsagel PL., Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma Cancer Cell Aug;12(2):131-44 2007
  • Chng WJ, Kumar S, Van Wier S, Ahmann G, Price-Troska T, Henderson K, Chung TH, Kim S, Mulligan G, Bryant B, Carpten J, Gertz M, Rajkumar SV, Lacy M, Dispenzieri A, Kyle R, Greipp P, Bergsagel PL, Fonseca R., Molecular dissection of hyperdiploid multiple myeloma by gene expression profiling Cancer Research Apr 1;67(7):2982-2989 2007
  • Silbergeld EK, Graham J, and Price LB., Industrial Food Animal Production, Antimicrobial Resistance, and Human Health Annu. Rev. Public Health, In Press 2008
  • Graham, JP, Leibler JH, Price LB, Otte JM, Pfeiffer DU, Tiensin T, and Silbergeld EK, The Animal:Human Interface and Infectious Disease in Industrial Food Animal Production: Rethinking Biosecurity and Biocontainment. Public Health Reports 123:1-30 2008
  • Price LB, Graham JP, Lackey L, Roess A, and Silbergeld E, Multidrug resistant Escherichia coli among US poultry workers. Environ Health Perspect 115:1738-1742 2007
  • Price LB, Lackey L, Vailes R and Silbergeld E. , The persistence of fluoroquinolone-resistant Campylobacter in poultry production Environ Health Perspect 115:1035-1039 2007
  • Price LB, Roess A, Graham JP, Baqar S, Vailes R, Sheikh KA, and Silbergeld E., Neurologic symptoms and neuropathologic antibodies in poultry workers exposed to Campylobacter jejuni. J Occ Environ Med, 49:748-55 2007
  • Keats JJ, Fonseca R, Chesi M, Schop R, Baker A, Chng WJ, Van Wier S, Tiedemann R, Shi CX, Sebag M, Braggio E, Henry T, Zhu YX, Fogle H, Price-Troska T, Ahmann G, Mancini C, Brents LA, Kumar S, Greipp P, Dispenzieri A, Bryant B, Mulligan G, Bruhn L, Barrett M, Valdez R, Trent J, Stewart AK, Carpten J, Bergsagel PL., Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell Aug;12(2):131-44. 2007
  • Price LB, Liu CM, Melendez JH, Frankel YM, Engelthaler D, Aziz M, Bowers J, Rattray R, Ravel J, Kingsley C, Keim PS, Lazarus GS, Zenilman JM. , Community analysis of chronic wound bacteria using a 16S rRNA gene-based pyrosequencing approach: impact of diabetes and antibiotics on chronic wound microbiota PLoS One ul 31;4(7):e6462 2009
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