Kendall Van Keuren-Jensen

Kendall Van Keuren-Jensen Ph.D.

Professor
Neurogenomics Division

Co-Director
Center for Noninvasive Diagnostics

Kendall Van Keuren-Jensen Ph.D.

Diseases and injuries of the central nervous system (CNS) are difficult to diagnose, monitor, and treat. The development of reliable mechanisms for early detection of illness and injury, before signs and symptom appear, may help to prevent secondary insult cascades and reduce long-term deficits in patients with neurological conditions or injuries. Permanency of damage to the CNS is time sensitive, in many cases once neurological involvement is severe enough to cause clinically detectable signs and symptoms, the damage becomes irreversible. Molecular changes in the CNS are difficult to monitor due to the inaccessibility of the tissue.

There has been significant interest in the utility of circulating extracellular vesicles (EVs) and RNA binding proteins (RBPs) as a proxy for monitoring CNS injury and disease. Circulating protein, RNA, metabolomic, and lipidomic materials are released from cells, protected from degradation by vesicle membranes or associated proteins. This molecular information, from every tissue, gets into bodily fluids and provides information about pathogenic processes associated with disease, injury, inflammation and damage in a minimally invasive way. EVs and RBPs provide us with a new handle for monitoring and understanding disease progression, identification of biomarkers, assay development, and therapeutic discovery. The minimally invasive nature for collecting extracellular information from biofluids allows for frequent sampling, with the potential to closely monitor pathophysiological mechanisms of traumatic injury and disease. 

Dr. Van Keuren-Jensen received her Ph.D. from Stonybrook University at Cold Spring Harbor Laboratory in New York where she studied the role of activity-regulated genes in synaptic transmission and neuronal morphology. Following her Ph.D., she was a postdoctoral fellow at Harvard Medical School for a short time before coming to TGen. She also has a Master’s degree in Pharmacology and Toxicology from the University of Kansas. She received her B.A. from Boston University.

  • Total Extracellular Small RNA Profiles from Plasma, Saliva, and Urine of Healthy Subjects. Yeri A, Courtright A, Reiman R, Carlson E, Beecroft T, Janss A, Siniard A, Richholt R, Balak C, Rozowsky J, Kitchen R, Hutchins E, Winarta J, McCoy R, Anastasi M, Kim S, Huentelman M, Van Keuren-Jensen K., Sci Rep. 2017, 7:44061.

    Two distinct extracellular RNA signatures released by a single cell type identified by microarray and next-generation sequencing. Lässer C, Shelke GV, Yeri A, Kim DK, Crescitelli R, Raimondo S, Sjöstrand M, Gho YS, Van Keuren Jensen K, Lötvall J. , RNA Biol. 2017 14(1):58-72. 

    Isolation, identification, and characterization of novel nanovesicles. OncotargetZhang HG, Cao P, Teng Y, Hu X, Wang Q, Yeri A, Zhuang X, Samykutty A, Mu J, Deng Z, Zhang L, Mobley J, Yan J, Van Keuren-Jensen K, Miller D. (2016), Oncotarget. 7(27):41346-41362

    Bringing RNA-seq closer to the clinicVan Keuren-Jensen K, Keats JJ, Craig DW. (2014) Nat Biotechnol. 32:884-5. 

    Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer’s and Parkinson’s diseases correlate with disease status and features of pathologyBurgos K*, Malenica I*, Metpally R, Courtright A, Rakela B, Beach T, Shill H, Adler C, Sabbagh M, Villa S, Tembe W, Craig D, Van Keuren-Jensen K., (2014) PLOS ONE 9(5):e94839.

  • RNA isolation for small RNA next-generation sequencing from acellular biofluids. Burgos KL, Van Keuren-Jensen K. (2014) Methods Mol Biol. 1182:83-92
  • Identification of extracellular miRNA in human cerebrospinal fluid by next-generaton sequencing. Burgos KL, Javaherian A, Bomprezzi R, Ghaffari L, Rhodes S, Courtright A, Tembe W, Kim S, Metpally R, Van Keuren-Jensen K. (2013) RNA, 19; 712:722.

  • Comparison of Analysis Tools for miRNA High Throughput Sequencing Using Nerve Crush as a Model. Metpally RP, Nasser S, Malenica I, Courtright A, Carlson E, Ghaffari L, Villa S, Tembe W, Van Keuren-Jensen K. (2013) Front Genet. 4(20), 1-13.

  • Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, Nalls MA, Chen K, Lee W, Chewning K, Villa SE, Meechoovet HB, Gerber JD, Frost D, Benson HL, O'Reilly S, Chibnik LB, Shulman JM, Singleton AB, Craig DW, Van Keuren-Jensen KR, Dunckley T, Bennett DA, De Jager PL, Heward C, Hardy J, Reiman EM, Huentelman MJ. Hum Mol Genet Aug 15;19(16):3295-301 2010
  • Homer Proteins Shape Xenopus Optic Tectal Cell Dendritic Arbor Development in Vivo. Van Keuren-Jensen K.R., and Cline H.T.  Developmental Neurobiology 68:1315-1324 2008
  • Ewald R, Van Keuren-Jensen KR, Aizenman CD, Cline H.T., Roles of NR2A and NR2B in the development of dendritic arbor morphology in vivo. Journal of Neuroscience, Vol 28: 850-861 2008
  • Van Keuren-Jensen, K and Cline, H.T., Visual Experience Regulates mGluR-mediated Plasticity of AMPAR Synaptic Transmission by Homer1a Induction. Journal of Neuroscience 26:7575-7580 2006
  • Foa, L, Van Keuren-Jensen, K, Rajan, I, Bronson, K, Gasperini, R, Worley, P.F., Tu, J.C., Cline, H.T.., Homer Expression in the Xenopus Tadpole Nervous System Journal of Comparative Neurology 487, 42-53 2005
  • Aizenman, C., Akerman, C., Van Keuren-Jensen, K., Cline, H.., Visually Driven Regulation of Intrinsic Neuronal Excitability Improves Stimulus Detection In Vivo Neuron 39, 831-842 2003.
  • Haas, K., Van Keuren-Jensen, K., Sin, W.C., Foa, L., Cline, H.T.., Targeted electroporation in Xenopus tadpoles in vivo from single cells to the entire brain Differentiation, 70 (4-5), 148-54 2002
  • Van Keuren-Jensen, K., de la Bastide, M., Parsons, R., Parnell, L.D., Dedhia, N., Gottesman, T., Gnoj, L., Kaplan, N., Lodhi, M., Johnson, A.F., Shohdy, N., Hasegawa, A., Haberman, K., Huang, E.N., Schutz, K., Calma, C., Granat, S., Wigler, M., McCombie, W.R., Genomic Sequence of PTEN/MMAC1 GenBank Accession AF067844 2002
  • Van Keuren-Jensen, K.R., Stodgell, C.J., Schroeder, S.R., Tessel, R.E., Fixed-ratio Discrimination Training as Replacement Therapy in Parkinson's Disease: Studies in a 6-hydroxydopamine-treated Rat Model Brain Research 780(1):56-66 1998
  • Lucito, R., Nakimura, M., West, J.A., Han, Y., Chin, K., Van Keuren-Jensen, K., McCombie, R., Gray, J.W., Wigler, M., Genetic Analysis Using Genomic Representations. Proceedings of the National Academy of Science 95(8):4487-92 1998
  • Frye, C.A., Van Keuren-Jensen, K.R., Erskine , M.S., Behavioral Effects of 3 alpha-androstanediol. I: Modulation of Sexual Receptivity and Promotion of GABA-stimulated Chloride Flux. Behavioral Brain Research, 79(1-2):109-18 1996
  • Frye, C.A., Van Keuren-Jensen, K.R., Rao, P.N., Erskine, M.S., Analgesic Effects Of The Neurosteroid 3 alpha-androstanediol. Brain Research 709(1):1-9 1996
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