Cheryl D. Cropp

Cheryl D. Cropp Pharm.D., Ph.D.

Assistant Professor
Integrated Cancer Genomics Division

Assistant Professor
Pharmacy Practice & Science, University of Arizona College of Pharmacy

Cheryl D. Cropp Pharm.D., Ph.D.

Cheryl D. Cropp, Pharm.D., Ph.D. is an Assistant Professor at the University of Arizona College of Pharmacy, Phoenix Biomedical Campus. She has a joint appointment at TGen as an Assistant Professor in the Integrated Cancer Genomics Division.   

Dr. Cropp has expertise in finding functional variants in healthy and health disparate world populations utilizing unrelated and family data. Dr. Cropp’s overall research goals are to elucidate the genetic determinants of disease that will assist in a refined understanding of the etiology of diseases such as cancer and will assist in narrowing the divide between the morbidity and mortality that currently exists within health disparate populations.  Notably, in previous work, her linkage analyses of Finnish prostate cancer families, led to a replication of a statistically significant linkage peak on chromosome 17q21-22. Ultimately, this finding led the International Consortium for Prostate Cancer Genetics (ICPCG) to discover the G84E variant in HOXB13, the first genetic variant to provide confirmation of an association of prostate cancer risk.

Currently, Dr. Cropp, a member of the International Consortium for Prostate Cancer Genetics (ICPCG) is leading a whole exome sequencing study of hereditary prostate cancer in African American families from the African American Hereditary Prostate Cancer (AAHPC) cohort, which could potentially develop into pharmacologic treatment response studies with other members of this consortium in the future.  Additionally, Dr. Cropp’s highlighted research work includes a collaboration to profile breast cancers from individuals with hereditary cancer syndromes.  Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare cancer for which little molecular data exists and few empirically derived treatment options exist.  Dr. Cropp is working towards the discovery of genes which coexist within both inherited and tumor matched SCCOHT samples from patients with or without germline SMARCA4 mutations to determine if they modify risk of developing this disease.  

Outside TGen, Dr. Cropp works closely with the University of Arizona College of Pharmacy to build their academic curriculum and advise pharmacy students on the Phoenix Biomedical Campus. Additionally, she has an ongoing collaboration with a renowned physician researcher at the Veterans Affairs Medical Center in Phoenix to study cardiovascular genetic epidemiology in the diabetic Veteran population.

 

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Common Variants at Putative Regulatory Sites of the Tissue Nonspecific Alkaline Phosphatase Gene Influence Circulating Pyridoxal 5’-Phosphate Concentration in Healthy Adults. Carter TC, Pangilinan F, Molloy AM, Fan R, Wang Y, Shane B, Gibney ER, Midttun Ø, Ueland PM, Cropp CD, Kim Y, Wilson AF, Bailey-Wilson JE, Brody LC, Mills JL. J Nutr. 2015;145:1386-1393.

8q24 risk alleles and prostate cancer in African-Barbadian menCropp CD, Robbins CM, Sheng X, Hennis AJ, Carpten JD, Waterman L, Worrell R, Schwantes-An TH, Trent JM, Haiman CA, Leske MC, Wu SY, Bailey-Wilson JE, Nemesure B. Prostate. 2014;74:1579-1588.

Genetic heterogeneity in Finnish hereditary prostate cancer using ordered subset analysis. Simpson CL, Cropp CD, Wahlfors T, Nati H, George A, Jones MPS, Harper U, Ponciano-Jackson D, Tammela T, Schleutker J, Bailey-Wilson JE. Eur J Hum Genet. 2013;21:437-443.

Racial disparities in the association between variants on 8q24 and prostate cancer: a systematic review and meta-analysis. Troutman SM, Sissung TM, Cropp CD, Venzon DJ, Spencer SD, Adesunloye BA, Huang X, Karzai FH, Price DK, Figg WD. Oncologist. 2012;17:312-320.

Genome-wide linkage scan for prostate cancer susceptibility in Finland: evidence for novel loci on 2q37.2 and confirmation of signal on 17q21-22. Cropp CD, Simpson CL, Wahlfors T, Nati H, George A, Jones MS, Harper U, Ponciano-Jackson D, Tammela T, Bailey-Wilson JE, Schleutker J. Int J Cancer. 2011;129:2400-2407.

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