Using the most advanced tools and technologies available, TGen is determined to develop revolutionary advances in treating and defeating this cancer through a better understanding of the underlying genetic causes of the disease.
MindCrowd® is the first online research project to help us discover how to reduce cognitive decline and disease as we age. Support helps us to find solutions for keeping our brains healthier and longer.
The Center for Rare Childhood Disorders
At the Center for Rare Childhood Disorders, our faculty are pioneers in deciphering the story a person’s genome tells. They can decipher a patient's genome and provide information to the physician —and families— about how best to attack a given disease.
The work being done under the direction of David Engelthaler, PhD, at TGen North, focuses on viruses such as the Valley Fever and comprehending its environmental impact, advancing diagnostic techniques, initiating early-phase drug development, and pinpointing potential vaccine candidates. Support aids the work being done to understand better how these pathogens spread over time and space.
In the Glioma Research Lab, the team is studying the changes in glioma gene expression, in various cancers such as DIPG, or Diffuse Intrinsic Pontine Gliomas, for which there is no known cure. These experiments are designed to discover key genetic regulation of the cancer cell transition from proliferative to migratory behaviors.
In the Diabetes and Fibrotic Disease Unit, the team studies a wide range of factors associated with diabetic kidney disease, nonalcoholic fatty liver disease (NAFLD), and diabetic dyslipidemia, all of which contribute significantly to morbidity and mortality in patients with diabetes.
Education for Future Scientists
TGen’s mission in science education and training is to educate, train, and inspire the next generation of researchers and physicians and to increase the community’s working knowledge of genomics.
Multiple Myeloma Research
In the Multiple Myeloma Research Laboratory, the team is working to identify the genetic events that lead to myeloma, a blood cancer that develops from the bone marrow. Support aids research to understand how some of the most frequently identified mutated genes are involved in the pathogenesis of multiple myeloma.
Neurological Disease Research
In the Center for Noninvasive Diagnostics, the team researches a wide variety of diseases affecting the central nervous system. Supporting this cause helps to develop reliable mechanisms for early detection of illness and injury that may help to prevent secondary insult cascades and reduce long-term deficits in patients with neurological conditions, such as Parkinson's and ALS.