TGen Research - Investigators and Advisors

Research Faculty


	Profile


	Selected Publications


	Resources

Rennstam K., A. Ringberg, H.E. Cunliffe, H. Olsson, G. Landberg, I. Hedenfalk. Genomic alterations in histopathologically normal breast tissue from BRCA1 mutation carriers may be caused by BRCA1 haploinsufficiency. Genes Chromosomes Cancer, 49(1):78-90. 2010.

Ariazi, E.A., S. Yerrum, E. Brailoiu, H.A. Shupp, M.J. Slifker, H.E. Cunliffe, M.A. Black, A.L. Donato, J.B. Arterburn, T.I. Oprea, E.R. Prossnitz, N.J. Dun and V. Craig Jordan. The G Protein-Coupled Receptor GPR30 Inhibits Proliferation of Estrogen Receptor-Positive Breast Cancer Cells. Cancer Research, 70(3):1184-94. 2010.

Lewis-Wambi J.S., H.E. Cunliffe, H.R. Kim, A.L. Willis, V.C. Jordan. Overexpression of CEACAM6 promotes migration and invasion of oestrogen-deprived breast cancer cells. Eur J Cancer., 44(12):1770-9. 2008.

Willis A.L., N.L. Tran, J.M. Chatigny, N. Charlton, H. Vu, S.A.N. Brown, M. Black, W.S. McDonough, S.P. Fortin, J.R. Niska, J.A. Winkles, H.E. Cunliffe. The Fn14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity. Molecular Cancer Res, 6(5):725-34. 2008.

Winkles J.A., N.L. Tran, S.A.N. Brown, N. Stains, H.E. Cunliffe, M.E. Berens. Role of TWEAK and Fn14 in tumor biology. Frontiers in Bioscience, 12, 2761-2771. 2007.

Jordan V.C., J. Lewis-Wambi, H. Kim, H. Cunliffe, E. Ariazi, C.G.N. Sharma, H.A Shuppa and R. Swaby. Exploiting the apoptotic actions of oestrogen to reverse antihormonal drug resistance in oestrogen receptor positive breast cancer patients. Breast, Dec;16 Suppl 2:105-13. 2007.

Jordan V.C., E.A. Ariazi, J.S. Lewis-Wambi, R.R. Swaby, H.E. Cunliffe, A.T. Riegel and A. Wellstein. Oestrogen is bad for patients with breast cancer?. Breast Cancer Res, 9(Suppl 2): S22. 2007.

Gruvberger-Saal S.K., H.E. Cunliffe, K.M. Carr and I.A. Hedenfalk. Microarrays in breast cancer research and clinical practice – the future lies ahead. Endocr-Relat Cancer, 13(4):1017-31. 2006.

Tran N.L., W.S. McDonough, B.A. Savitch, S.P. Fortin, J.A. Winkles, M. Symons, M. Nakada, H.E. Cunliffe, G. Hostetter, D.B. Hoelzinger, J.L. Rennert, J.S. Michaelson, L.C. Burkly, C.A. Lipinski, J.C. Loftus, L. Mariani, M.E. Berens. Fn14 receptor activation induces Fn14 expression and malignant glioma progression via Rac1 and NF-κB. Cancer Res, 66(19):9535-42. 2006.

Cunliffe, H.E., M. Ringner, S. Bilke, R.L. Walker, J.M. Cheung, Y. Chen, P.S. Meltzer. The gene expression response of breast cancer to growth regulators: patterns and correlation with tumor expression profiles. Cancer Res., Nov 1;63(21):7158-66. 2003.

Azorsa, D. O., H.E. Cunliffe, and P.S. Meltzer. Association of steroid receptor coactivator AIB1 with estrogen receptor- alpha in breast cancer cells. Breast Cancer Res Treat, 70, 89-101. 2001.

Scherr, M., J. LeBon, D. Castanotto, H.E. Cunliffe, P.S. Meltzer, A. Ganser, A.D. Riggs and J.J. Rossi. Detection of antisense and ribozyme accessible sites on native mRNAs: application to NCOA3 mRNA. Mol Ther, 4, 454-460. 2001.

Wilderman, P.J., A.L. Vasil, Z. Johnson, M.J. Wilson, H.E. Cunliffe, I.L. Lamont and M.L. Vasil. Characterization of an endoprotease (PrpL) encoded by a PvdS-regulated gene in Pseudomonas aeruginosa. Infection and Immunity, 69(9): 5385-94. 2001.

Porteous, S., E. Torban, N.P. Cho, H.E. Cunliffe, L. Chua, L. McNoe, T. Ward, C. Souza,P. Gus, R. Giugliani, et al.. Primary renal hypoplasia in humans and mice with PAX2 mutations: evidence of increased apoptosis in fetal kidneys of Pax2(1Neu) +/- mutant mice. Hum Mol Genet, 9, 1-11. 2000.

Stayner, C. K., H.E. Cunliffe, T. Ward, and M.R. Eccles. Cloning and characterization of the human PAX2 promoter. J Biol Chem, 273, 25472-25479. 1998.

Cunliffe, H. E., L.A. McNoe, T.A. Ward, K. Devriendt, H.G. Brunner, and M.R. Eccles. The prevalence of PAX2 mutations in patients with isolated colobomas or colobomas associated with urogenital anomalies. J Med Genet, 35, 806-812. 1998.

Cunliffe, H. E., Schimmenti, L. A., McNoe, L. A., Ward, T. A., French, M. C., Shim, H. H., Zhang, Y. H., Proesmans, W., Leys, A., Byerly, K. A., et al.. Further delineation of renal-coloboma syndrome in patients with extreme variability of phenotype and identical PAX2 mutations. Am J Hum Genet, 60, 869-878. 1997.

McConnell, M. J., H.E. Cunliffe, L. J. Chua, T.A. Ward, and M.R. Eccles. Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2. Oncogene, 14, 2689-2700. 1997.