TGen Research - Investigators and Advisors

Research Faculty


	Profile


	Selected Publications

Craig DW, Itty A, Panganiban C, Szelinger S, Kruer MC, Sekar A, Reiman D, Narayanan V, Stephan DA, Kerrigan JF. Identification of somatic chromosomal abnormalities in hypothalamic hamartoma tissue at the GLI3 locus. American Journal of Human Genetics, 82(2):366-74. 2008.

Homer N, Tembe WD, Szelinger S, Redman M, Stephan DA, Pearson JV, Nelson SF, Craig D. Multimarker analysis and imputation of multiple platform pooling-based genome-wide association studies. Bioinformatics, 24(17):1896-902. 2008.

Homer N, Szelinger S, Redman M, Duggan D, Tembe W, Muehling J, Pearson JV, Stephan DA, Nelson SF, Craig DW. Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays. PLoS Genetics, 29; 4(8). 2008.

Craig DW, Pearson JV, Szelinger S, Sekar A, Redman M, Corneveaux JJ, Pawlowski TL, Laub T, Nunn G, Stephan DA, Homer N, Huentelman MJ. Identification of genetic variants using bar-coded multiplexed sequencing. Nature Methods, 5(10):887-93. 2008.

Brown KM, MacGregor S, Montgomery GW, Craig DW, Zhao Z, Iyadurai K, Henders A, Homer N, Campbell M, Stark M, Thomas S, Schmid H, Holland EA, Gillanders EM, Duffy DL, Maskiell JA, Jetann J, Ferguson M, Stephan DA, Cust AE, Whiteman D, Green A, Olsson H, Puig S, Ghiorzo P, Hansson J, Demenais F, Goldstein AM, Gruis NA, Elder DE, Newton-Bishop J, Kefford RF, Giles GG, Armstrong BK, Aitken JF, Hopper JL, Martin NG, Trent JM, Mann GJ, Hayward NK. Common sequence variants on 20q11.22 confer melanoma susceptibility. Nature Genetics, 40(7):838-40. Epub 2008 May 18. 2008.

Webster JA, Myers AJ, Pearson JV, Craig DW, Hu-Lince D, Coon KD, Zismann VL, Beach T, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Huentelman MJ, Joshipura K, Walker D, Heward CB, Ravid R, Rogers J, Papassotiropoulos A, Hardy J, Reiman EM, Stephan DA. Sorl1 as an Alzheimer's disease predisposition gene?. Neurodegener Dis, 5(2):60-4. 2008.

Comabella M, Craig DW, Camiña-Tato M, Morcillo C, Lopez C, Navarro A, Rio J; BiomarkerMS Study Group, Montalban X, Martin R. Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a genome-wide scan of 500,000 single nucleotide polymorphisms PLoS ONE, 3(10):e3490. 2008.

Lesch KP, Timmesfeld N, Renner TJ, Halperin R, Röser C, Nguyen TT, Craig DW, Romanos J, Heine M, Meyer J, Freitag C, Warnke A, Romanos M, Schäfer H, Walitza S, Reif A, Stephan DA, Jacob C. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. J Neural Transm, 115(11):1573-85. 2008.

Hanson RL , Craig DW, Millis MP, Yeatts KA, Kobes S, Pearson JV, Lee AM, Knowler WC, Nelson RG, Wolford JK. Identification of PVT1 as a candidate gene for end-stage renal disease in Type 2 Diabetes using a pooling-based genome-wide SNP association study. Diabetes, Apr;56(4):975-83. 2007.

Melquist S, Craig DW, Huentelman MJ, Crook R, Pearson JV, Baker M, Zismann VL, Gass J, Adamson J, Szelinger S, Corneveaux J, Cannon A, Coon KD, Lincoln S, Adler C, Tuite P, Calne DB, Bigio EH, Uitti RJ, Wszolek ZK, Golbe LI, Caselli RJ, Graff-Radford N, Litvan I, Farrer MJ, Dickson DW, Hutton M, Stephan DA. Identification of a Novel Risk Locus for Progressive Supranuclear Palsy by a Pooled Genomewide Scan of 500,288 Single-Nucleotide Polymorphisms. Am J Hum Genet, Jan;80(4):769-778. 2007.

Pearson JV, Huentelman MJ, Halperin RF, Tembe WD, Melquist S, Homer N, Brun M, Szelinger S, Coon KD, Zismann VL, Webster JA, Beach T, Sando SB, Aasly JO, Heun R, Jessen F, Kolsch H, Tsolaki M, Daniilidou M, Reiman EM, Papassotiropoulos A, Hutton ML, Stephan DA, Craig DW. Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies. Am J Hum Genet, Jan;80(1):126-39. 2007.

Corneveaux JJ, Kruer MC, Hu-Lince D, Ramsey KE, Zismann VL, Stephan DA, Craig DW, Huentelman MJ. SNP-based chromosomal copy number ascertainment following multiple displacement whole-genome amplification. Biotechniques, Jan;42(1):77-83. 2007.

Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert (Robeson) RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA. GAB2 alleles modify Alzheimer’s risk in APOE varepsilon4 carriers. Neuron, 54(5): 713-720. 2007.

Kerrigan JF, Craig DW, Kruer MC, Corneveaux JJ, Panganiban CB, Itty A, Reiman D, Ng YT, Stephan DA. Chromosomal Abnormality at 6p25.1-25.3 Identifies A Susceptibility Locus For Hypothalamic Hamartoma Associated With Epilepsy. Epilepsy Res., 75(1):70-3. 2007.

Hanson RL, Craig DW, Millis MP, Yeatts KA, Kobes S, Pearson JV, Lee AM, Knowler WC, Nelson RG, Wolford (DiStefano) JK. Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study. Diabetes, 56 (4):975-83. 2007.

Dunckley T, Huentelman MJ, Craig DW, Pearson JV, Szelinger S, Joshipura K, Halperin RF, Stamper C, Jensen KR, Letizia D, Hesterlee SE, Pestronk A, Levine T, Bertorini T, Graves MC, Mozaffar T, Jackson CE, Bosch P, McVey A, Dick A, Barohn R, Lomen-Hoerth C, Rosenfeld J, O'connor DT, Zhang K, Crook R, Ryberg H, Hutton M, Katz J, Simpson EP, Mitsumoto H, Bowser R, Miller RG, Appel SH, Stephan DA. Whole-genome analysis of sporadic amyotrophic lateral sclerosis. New England Journal of Medicine, 357(8):775-88. 2007.

Myers AJ, Gibbs JR, Webster JA, Rohrer K, Zhao A, Marlowe L, Kaleem M, Leung D, Bryden L, Nath P, Zismann VL, Joshipura K, Huentelman MJ, Hu-Lince D, Coon KD, Craig DW, Pearson JV, Holmans P, Heward CB, Reiman EM, Stephan D, Hardy J. A survey of genetic human cortical gene expression. Nat Genet, 39(12):1494-9. 2007.

Hua, J, Craig DW, Brun M, Webster J, Zismann VL, Tembe W, Joshipura K, Huentelman MJ, Dougherty ER, Stephan DA. SNiPer-HD: Improved genotype calling accuracy by an expectation-maximization algorithm for high-density SNP arrays. Bioinformatics, 23(1):57-63. 2007.

Puffenberger EG, Strauss KA, Ramsey KE, Craig DW, Stephan DA, Robinson DL, Hendrickson CL, Gottlieb S, Ramsay DA, Siu VM, Heuer GG, Crino PB, Morton DH. Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5. Brain, May 23 (Epub ahead of print). 2007.

Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A,Coluccia D, Hanggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ. Common Kibra alleles are associated with human memory performance. Science, Oct 20;314(5798):475-8. 2006.

Craig DW, Huentelman MJ, Hu-Lince D, Zismann VL, Kruer MC, Lee AM, Puffenberger EG, Pearson JM, Stephan DA. Identification of disease causing loci using an array-based genotyping approach on pooled DNA. BMC Genomics, Sep 30;6:138. 2005.

Huentelman MJ, Craig DW, Shieh AD, Corneveaux JJ, Hu-Lince D, Pearson JV, Stephan DA. SNiPer: improved SNP genotype calling for Affymetrix 10K GeneChip microarray data. BMC Genomics, Oct 31;6:149. 2005.

Strauss KA, Puffenberger EG, Craig DW, Panganiban CB, Lee AM, Hu-Lince D, Stephan DA, Morton DH. Genome-wide SNP arrays as a diagnostic tool: clinical description, genetic mapping, and molecular characterization of Salla disease in an Old Order Mennonite population. American Journal of Medical Genetics, 15;138A(3):262-7. 2005.

Hu-Lince D, Craig DW, Huentelman MJ, Stephan DA. The Autism Genome Project: Goals and Strategies. Am J Pharm, 5(4): 233-246. 2005.

Craig DW and Stephan DA. Applications of High Density Whole-Genome Genotyping. Expert Rev Mol Diagn, 5(2):159-70. 2005.

Puffenberger E.G., Hu-Lince D., Parod J.M., Craig D.W., Dobrin S.E., Conway A.R., (Stephan) Donarum E.A., Strauss K.A., Dunckley T., Cardenas J.F., Melmed K.R., Wright C.A., Liang W., Stafford P., Flynn C.R., Morton D.H., Stephan D.A.. Mapping of sudden infant death with dysgenesis of the testes syndrome (SIDDT) by a SNP genome scan and identification of TSPYL loss of function. Proc Natl Acad Sci U S A, 10;101(32):11689-94 . 2004.

Craig, D., Gao, M., Schulten, K. & Vogel, V.. Tuning the Mechanical Stability of Fibronectin Type III Modules through Sequence Variations. Structure (Camb) - Commentary in same issue, 12, 21-30. 2004.

Craig DW, Gao M, Schulten K, and Vogel V. Structural insights into how the MIDAS ion stabilizes integrin binding to an RGD peptide under force. Structure (Camb), 12(11):2049-58. 2004.

Gao, M.* Craig, D.* et. al. *These authors contributed equally to this work.. Structure and functional significance of mechanically unfolded fibronectin type III1 intermediates. Proc Natl Acad Sci, 100, 14784-9. 2003.

Craig, Krammer, Schulten, Vogel.. Comparison of the early stages of forced unfolding for fibronectin type III modules. Proc Natl Acad Sci, 98(10),5590-5. 2001.

Vogel V, Thomas W, Craig DW, Krammer A, and Baneyx G. Structural insights into the mechanical regulation of molecular recognition sites. Trends Biotechnol, 19:416.. 2001.

Craig DW and Betterton EA. Kinetics and mechanism of the reaction of azide with ozone in aqueous solution. J Air Waste Mgmt, 49:1347-1354. 1999.

Johnson B, Betterton EA, and Craig DW. Henry's Law coefficients for formic and acetic acids. J Atmos Chem, . 1996.