TGen Research - Investigators and Advisors

Research Faculty


	Profile


	Selected Publications

Robeson, RH, Siegel AM, Dunckley T. Genomic and proteomic biomarker discovery in neurological disease. Biomarker Insights, (3) 73-86. 2008.

Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ. Evidence for an association between KIBRA and late-onset Alzheimer's disease. Neurobiology of Aging, 11. 2008.

Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA. Altered neuronal gene expression in brain regions differentially affected by Alzheimer’s Disease: A reference data set. Physiological Genomics, 33(2): 240-56. 2008.

Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, Niedzielko TL, Schneider LE, Mastroeni D, Caselli R, Kukull W, Morris JC, Hulette CM, Schmechel D, Roger J, Stephan DA. Alzheimer’s Disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc Natl Acad Sci USA, 105(11): 4441-6. 2008.

Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA. Neuronal gene expression in non-demented individuals with Alzheimer’s Disease neuropathology. Neurobiology of Aging, Epub. 2008.

Stamper C, Siegel A, Liang WS, Pearson JV, Stephan DA, Shill H, Connor D, Caviness JN, Sabbagh M, Beach TG, Adler CH, Dunckley T. Neuronal gene expression correlates of Parkinson’s disease with dementia Mov Disord, 23:1588-1595. 2008.

Coon KD, Dunckley T, Stephan DA. A generic research paradigm for identification and validation of early molecular diagnostics and new therapeutics in common disorders. Mol Diagn Ther, 11(1):1-14. 2007.

Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Walker DG, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette C, Schmechel D, Alexandar GE, Reiman EM, Rogers J, Stephan DA. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. Physiological Genomics, 28(3):311-322. 2007.

Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert (Robeson) RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA. GAB2 alleles modify Alzheimer’s risk in APOE varepsilon4 carriers. Neuron, 54(5): 713-720. 2007.

Dunckley T, Huentelman MJ, Craig DW, Pearson JV, Szelinger S, Joshipura K, Halperin RF, Stamper C, Jensen KR, Letizia D, Hesterlee SE, Pestronk A, Levine T, Bertorini T, Graves MC, Mozaffar T, Jackson CE, Bosch P, McVey A, Dick A, Barohn R, Lomen-Hoerth C, Rosenfeld J, O'connor DT, Zhang K, Crook R, Ryberg H, Hutton M, Katz J, Simpson EP, Mitsumoto H, Bowser R, Miller RG, Appel SH, Stephan DA. Whole-genome analysis of sporadic amyotrophic lateral sclerosis. New England Journal of Medicine, 357(8):775-88. 2007.

Dunckley T, Coon KD, Stephan DA. Genetic Information and Cancer In: Ganten, D & Ruckpaul, K (eds). Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Springer, Berlin Heidelberg New York, pp 693-696. 2006.

Coon KD, Valla J, Szelinger S, Schneider LE, Niedzielko TL, Brown KM, Pearson JV, Halperin R, Dunckley T, Papassotiropoulos A, Caselli RJ, Reiman EM, Stephan DA. Quantitation of heteroplasmy of mtDNA sequence variants identified in a population of AD patients and controls by array-based resequencing. Mitochondrion, July 21. 2006.

Dunckley T, Liang WS, & Stephan DA. Evolution of Translational Genomic Research Strategies. Nova Science Publishers, Inc., Trends in Genome Research (Textbook) pp1-24. 2006.

Dunckley T, Beach TG, Ramsey KE, Grover A, Mastroeni D, Walker DG, Lafleur BJ, Coon KD, Brown KM, Caselli R, Kukull W, Higdon R, McKeel D, Morris JC, Hulette C, Schmechel D, Reiman EM, Rogers J, Stephan DA. Gene expression correlates of neurofibrillary tangles in Alzheimer's disease. Neurobiology of Aging, 27(10):1359-71.. 2006.

Dunckley T and Lukas R. Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res, 1116: 39-49. 2006.

Coon KD, Siegel AM, Yee SJ, Dunckley TL, Mueller C, Nagra RM, Tourtellotte WW, Reiman EM. Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease J Alzheimers Dis, 9: 225-233. 2006.

Segal SP, Dunckley T, Parker R. Sbp1p affects translational repression and decapping in Saccharomyces cerevisiae Mol Cell Biol, 26: 5120-5130. 2006.

Papassotiropoulos A, Fountoulakis M, Dunckley T, Stephan DA, Reiman EM. Genetics, Transcriptomics and Proteomics of Alzheimer's Disease J. Clin. Psych, 67: 652-670. 2006.

Dunckley T, Coon KD, Stephan DA. Discovery and development of biomarkers of neurological disease. Drug Discov Today, In Press. 2005.

Puffenberger, EG; Hu-Line, D; Parod, JM; Dobrin, SE; Craig, DW; Conway, AR; Stafford, PNMI; Donarum, EZ; Strauss, KA; Dunckley, T; Cardenas, JF; Melmed, KR; Wright, CA; Flynn, CA;Morton, DH; and Stephan, DA.. A high-density SNP genome scan identifies TSPYL loss-of-function as causative of swarey syndrome. Proc Natl Acad Sci, In Press. 2004.

Coon KD, Dunckley T, Stephan DA.. Biomarker identification in neurologic diseases: improving diagnostics and therapeutics. Expert Rev Mol Diagn, 4(3), 361-75. 2004.

Dunckley T, and Lukas R.. Nicotine modulates the expression of a diverse set of genes in the human neuronal SH-SY5Y cell line. J Biol Chem, 278,15633-15640. 2003.

Dunckley T, Lingke Z, Wu J, Lukas R.. Mutational analysis of roles for extracellular cysteine residues in assembly and function of human α7 nicotinic acetylcholine receptors. Biochemistry, 42,870-876. 2002.

Dunckley T, Parker R.. The yeast mRNA decapping enzyme. Methods Enzymol, 342,226-33. 2001.

Dunckley T, Tucker M, Parker R.. Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Genetics, 157, 27-37. 2000.

Dunckley T, Parker R.. The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. EMBO J, 18,5411-5422. 1999.